Standardized assessment of disease status in patients with primary Sjögren's syndrome: the foundation for creating criteria for disease activity and damage?
Identifieur interne : 002728 ( Main/Exploration ); précédent : 002727; suivant : 002729Standardized assessment of disease status in patients with primary Sjögren's syndrome: the foundation for creating criteria for disease activity and damage?
Auteurs : P. Oxholm [Danemark] ; K. Asmussen [Danemark]Source :
- Medical Hypotheses [ 0306-9877 ] ; 1998.
English descriptors
- Teeft :
- Acta ophthalmol, Arthritis rheum, Autoantibody, Autoimmune, Blood levels, Carbon anhydrase, Clin, Clin rheumatol, Clinical data, Clinical disease manifestations, Clinical manifestations, Clinical status, Clinical trials, Copenhagen county hospital, Cytokine, Diffusion capacity, Disease activity, Disease duration, Disease manifestations, Disease markers, Disease onset, Disease processes, Disease status, Exocrine, Exocrine autoimmunity, Exocrine glands, Exocrine immunoinflammation, Exocrine lymphoproliferation, Exocrine manifestations, Immunological aspects, Immunopathological features, Irreversible organ injuries, Labial, Laboratory markers, Langerhans cells, Literature survey, Longitudinal, Longitudinal analysis, Longitudinal course, Longitudinal studies, Longitudinal study, Lung function, Lymphocyte, Lymphocyte activity, Lymphocyte disease, Lymphocyte products, Lymphoproliferation, Manifestation, Manthorpe, Mast cells, Medical hypotheses, Medical treatment, Moutsopoulos, Nonexocrine, Nonexocrine manifestations, Ocular exocrine disease, Oral pathol, Organ damage, Oxholm, Pathogenesis, Plasma cells, Present data, Primary syndrome, Receptor, Retrospective study, Rheum, Rheumatic diseases, Rheumatoid factors, Rheumatol, Salivary, Salivary glands, Scand, Semin arthritis rheum, Soluble interleukin, Soluble markers, Standardized assessment, Surface exocrine manifestations, Syndrome, Vascular disease, Year period.
Abstract
Abstract: Primary Sjögren's syndrome (pSS) is increasingly acknowledged as a disease entity with consistent pathogenesis and clinical presentation. This has encouraged proposals for uniform nomenclature, as well as for classification of disease subsets and clinical disease manifestations. The purpose of this literature survey is to analyse present pathogenetic and clinical data on pSS from the viewpoint of their usability for developing criteria for activity and damage. It appears that the routinely used tests for evaluating clinical disease manifestations in pSS probably measure both activity and damage. Moreover, no immunopathogenic marker has been shown to adequately represent all aspects of disease activity in pSS. The survey demonstrates the need for longitudinal studies in which potential markers of disease activity and damage are validated.
Url:
DOI: 10.1016/S0306-9877(98)90268-7
Affiliations:
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This has encouraged proposals for uniform nomenclature, as well as for classification of disease subsets and clinical disease manifestations. The purpose of this literature survey is to analyse present pathogenetic and clinical data on pSS from the viewpoint of their usability for developing criteria for activity and damage. It appears that the routinely used tests for evaluating clinical disease manifestations in pSS probably measure both activity and damage. Moreover, no immunopathogenic marker has been shown to adequately represent all aspects of disease activity in pSS. 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